Will Ferrell, Pearl Jam’s Eddie Vedder and Mike McCready, Red Hot Chili Peppers’ Chad Smith, Brandi Carlile and Dave Matthews Band’s Stefan Lessard made one hell of a supergroup Monday as they joined forces to perform at a Seattle charity concert.

The stars came together to belt out Depeche Mode’s “Personal Jesus” at the bash, which was thrown to raise money for Cancer for College — a nonprofit organization that offers scholarships to low-income cancer survivors.

Ferrell, 50, opened the show by saying he wanted to bring a “local, homegrown kid” up on stage after pretending to soundcheck by shouting “one, two…” into the microphone.

The actor told the crowd, “We’ve got someone else who wants to try out for this band. So I want to bring him out and see if he wants to play.”

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His musical accomplice turned out to be none other than Eddie Vedder, 53, who was rocking the tambourine, while Ferrell played his trademark cowbell.

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Chad Smith, 56, who bears a striking resemblance to Ferrell, poked fun at his doppelganger once again at the show, which is thought to have raised more than $300,000 for the charity.

“The dueling do-gooder doppelgangers strike Seattle again!” the drummer joked.