Onscreen BFFs Drew Barrymore and Toni Collette delighted fans at the Toronto International Film Festival today with their touching dramedy, “Miss You Already”;.

In this new film from “Twilight”; director Catherine Hardwicke, Barrymore and Collette play life-long girlfriends who are put to the test when one struggles to start a family while the other one falls deathly ill.

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A tearjerker it is, but it also has plenty of laughs in between, with Collette playing a woman battling aggressive breast cancer and Barrymore going through expensive fertility treatments to become pregnant.

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The stars joined us live from the red carpet at Roy Thomson Hall on Saturday – watch below.