Charlize Theron is the Richard Gere to Seth Rogen’s Julia Roberts in the first trailer for “Long Shot”.

The two stars are hooking up for Jonathan Levine’s upcoming romantic-comedy which focuses on a U.S. Secretary of State (Theron) who enlists a hapless journalist (Rogen) to help with her speech-writing when she decides to run for president.

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Rogen’s character, Fred Flarsky, is regarded as a good writer but socially awkward and an outsider in the world of the political elite, while Theron’s Charlotte Field, who used to babysit Fred when they were kids, is a highly respected and powerful figure.

It looks like your typical odd-couple rom-com with two opposites coming together and eventually realizing they have more in common than they initially thought, except this time the movie is tackling the theme head-on.

“We asked a thousand constituents how they would feel if Kate Middleton were to start dating Danny DeVito,” June Diane Raphael’s character tells Theron. “Pretty negative reaction.”

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“Long Shot”  also stars Bob Odenkirk, O’Shea Jackson Jr., Andy Serkis, Ravi Patel, Randall Park, and Alexander Skarsgård.

Despite the political setting, Rogen recently told Entertainment Weekly that the film is more focused on the rom-com aspect than making a political statement.

“We wanted to make a movie that acknowledged the political realities we all live in without trying to make too heavy-handed directives,” he said. “And at the same time make something that’s highly enjoyable and highly entertaining that appeals to as wide an audience as anything I’ve made.”

The film will premiere at the SXSW Film Festival in March ahead of its wide release in theatres on May 3.