Kaley Cuoco is paying tribute to a very special “Big Bang Theory” fan.

On Thursday, the actress shared a series of photos on her Instagram account with Isaiah Zarate, a fan of the show who has Epidermolysis Bullosa (EB), a rare skin disorder.

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Cuoco said that the night’s new episode was dedicated to Zarate, who has been in the front row of the “Big Bang Theory” live audience for the whole Season 12 run.

Cuoco posted about her inspiring friend before, in 2007.

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The actress is also involved with the Epidermolysis Bullosa Medical Research Foundation, which raises money to fund the study of EB.