Kaley Cuoco Dedicates ‘Big Bang Theory’ Episode To Fan With Rare Skin Disorder

Kaley Cuoco is paying tribute to a very special “Big Bang Theory” fan.

On Thursday, the actress shared a series of photos on her Instagram account with Isaiah Zarate, a fan of the show who has Epidermolysis Bullosa (EB), a rare skin disorder.

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Cuoco said that the night’s new episode was dedicated to Zarate, who has been in the front row of the “Big Bang Theory” live audience for the whole Season 12 run.

View this post on Instagram

Tonight’s NEW episode @bigbangtheory_cbs is in honor of my sensational friend Isaiah @redguy29 ! He has sat in the front row of our audience for the entire run of season 12. He suffers from @ebmrf , yet when I look into the crowd, he always has the biggest smile on his face. He has become quite a key player here at BBT and I couldn’t love him more. Isaiah, thank you for always reminding me how a smile can change an entire day. You are an inspiration and I will fight with you to find a cure!! 🦋 ❤️

A post shared by Kaley Cuoco (@kaleycuoco) on Apr 25, 2019 at 11:05am PDT

Cuoco posted about her inspiring friend before, in 2007.

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My buddy @zarateisaiah came to visit me again @bigbangtheory_cbs ! Adore him! 💕 #ebkids #findacure 🦋

A post shared by Kaley Cuoco (@kaleycuoco) on Apr 18, 2017 at 10:46pm PDT

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The actress is also involved with the Epidermolysis Bullosa Medical Research Foundation, which raises money to fund the study of EB.