Isla Fisher has a warning for anyone interested in her sexually.

The “Wedding Crashers” star was on “Lights Out with David Spade” on Tuesday when the host brought up a story about dolphins getting high on pufferfish toxins.

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He asked Fisher if she had any pufferfish at home, to which she joked, “Yeah, my vagina.

“And it also releases a poisonous toxin when animals go try to eat it.”

Fellow guest Greg Fitzsimmons also joked about SeaWorld turning the pufferfish into a new attraction.

“Just toss a couple of those in the dolphin tank. It’s like spiking the punch,” he said. “When they throw the hoops, instead of catching them on their nose, they’re going to grab them on their rock-hard c**ks.”

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Earlier in the conversation, the host also cracked jokes about Jamie Foxx and Katie Holmes’ reported split.

“Dave, you probably don’t even know what breaking up is, right?” Fisher shot back, “because you have to actually be in a relationship.”