The actress, 37, was left petrified after eerie things started happening during a press junket for the new movie.
The big-screen adaptation of the classic H.G. Wells novel sees Moss play a woman who is being preyed upon by an invisible presence.
A new video released by the movie’s official Twitter account shows journalists and cast members preparing for interviews before ghostly things begin happening around them.
“So the gimmick is that they interview one of the stunt co-ordinators, at which point we are free to do what we do”, explains experiential director Josh Randall.
Cases slam shut, objects fly around the studio by themselves, and an eerie voice states, “You shouldn’t be here!”
The hilarious footage shows a terrified Moss clinging to co-star Oliver Jackson-Cohen for protection.
Paying a visit to “Late Night with Seth Meyers” on Thursday, Feb. 27, “The Handmaid’s Tale” star admitted to being “legitimately scared” during the prank.
She said: “They tried to scare us, they pulled us into a room. We sat down and started taking pictures of each other, just stupid – and then, they started to really really scare us.
“They had this whole magic thing that they did and they did all the tricks that they do in the movie. We actually legitimately got really scared.”
Moss added: “I immediately did the anti-feminist thing and like threw myself into his arms. I, like, lost a shoe. I was not the superhero that I am in this movie at all.”
“The Invisible Man” hits theatres on Feb. 28.