On Wednesday night, Vice President Mike Pence and Democratic candidate Joe Biden’s running mate, Kamala Harris, faced off in a debate between the number twos as celebrities shared their best reactions and hottest takes on social media. It was the second of four scheduled meetings between the two tickets ahead of the 2020 presidential election.

After a contentious debate between President Donald Trump and Biden the previous week, Pence and Harris convened at the University of Utah under strict COVID-19 protocols for a debate moderated by USA Today Washington bureau chief Susan Page. The six topics highlighted over the 90-minute event included Trump and Biden’s records, the Supreme Court, race and violence in America, the economy, the integrity of the election, and the handling of the novel coronavirus, COVID-19, which the president tested positive for this past Friday.

Jimmy Kimmel recapped the debate on “Jimmy Kimmel Live!” later Wednesday night.

“This debate is important because one of these people could be our president some day. For Mike Pence, the day could be tomorrow,” he joked.

Not surprisingly, Trump’s handling of the infectious and potentially deadly disease and recent comments dismissing the severity of the pandemic was addressed head-on as each candidate sat 12 feet apart behind plexiglass. “The American people have witnessed what is the greatest failure of any presidential administration in the history of our country,” Harris said off the bat, as Pence shook his head in disbelief.

Other viral moments included Harris’ reaction to Pence, when he tried to interrupt her early on. The candidate responded with, “Mr. President, I’m speaking,” much to the delight of fans on Twitter.

Everyone also loved Harris’ many reactions to Pence, including side-eye and seemingly sidelong glances of disbelief as he defended the Trump administration.

Additionally, celebs made jokes about Pence throughout the night, focused on everything from his disconcerting pink eye to his responses to anytime he went over his allotted two minutes.

Near the end of the night, an unexpected fly landed on Pence’s head, causing an eruption of responses.

Wednesday’s broadcast marked the first and only formal debate between the vice presidential candidates. Trump and Biden are slated to meet again for the third and fourth debates of the presidential race, which are currently scheduled for Oct. 15 and Oct. 22.

RELATED CONTENT:

Election 2020: How to Register to Vote, Get Mail-In Ballots and More

Voting by Mail: Everything You Need to Know

How to Watch the Second Presidential Debate Between Biden and Trump