Guelph, Ontario native Neve Campbell, 23 at the time, was starring on the hit TV show "Party Of Five" when she was cast as Sidney Prescott in "Scream".
Courteney Cox traded in her "Friends" role as good girl Monica Geller to play ambitious weather reporter Gale Weathers in "Scream".
Courteney Cox's "Friends" pals David Schwimmer and Matt LeBlanc hit the Los Angeles red carpet for the "Scream" premiere.
Matthew Perry came out to support "Friends" co-star Courteney Cox at the premiere of "Scream".
Jennifer Aniston And Tate Donovan
Jennifer Aniston sported her signature Rachel Green 'do at the "Scream" premiere next to then-boyfriend, actor Tate Donovan.
A 20-year-old Reese Witherspoon had just starred with Mark Wahlberg in the 1996 movie "Fear" when she hit the red carpet for "Scream".
Funnyman Matthew Lillard may not have made it out of "Scream" alive, but if you look closely, you can spot him in a cameo in a party scene a year later in "Scream 2".
Outspoken actress Rose McGowan channelled her "Scream" fame into starring roles in a strong run of indie flicks until landing the role of Paige Matthews in "Charmed" in 2011.
Skeet Ulrich cashed in on his Johnny Depp-like looks to play the heartthrob boyfriend and murder mastermind Billy Loomis in "Scream".
Patrick Dempsey had hit it big in the late 1980s but was still nearly a decade from McDreamy on "Grey's Anatomy" when he hit the red carpet for "Scream".