'Saturday Night Live' (1982-1985)
Julia Louis-Dreyfus and future husband Brad Hall were both cast in the 1982 season of "Saturday Night Live".
Looking back, she recalled the attitude toward the show's female performers to be "sexist," remembering her three seasons on the show as "a very brutal time."
However, she did take away an important lesson from the experience, admitting she "learned I wasn’t going to do anymore of this show-business crap unless it was fun."
'National Lampoon's Christmas Vacation' (1989)
Each Christmas, families gather around their TV screens for the annual viewing of the Chevy Chase holiday classic, and each year are reminded, that's right Julia Louis-Dreyfus played half of the obnoxious yuppie couple who lived next door to the Griswolds.
Of all the iconic roles in her career, it's doubtful Louis-Dreyfus will ever top her performance as Elaine Benes in "Seinfeld".
From determining whether a man is "sponge-worthy" to showing off the most horrific dance moves to ever emanate from a TV screen, Louis-Dreyfus deservedly racked up six Emmy nominations, but surprisingly just one win.
'A Bug's Life' (1998)
Julia Louis-Dreyfus' distinctive voice could be heard portraying Princess Atta in Pixar's "A Bug's Life".
Interestingly enough, co-star Jerry Seinfeld would also go on to play a CGI-animated insect on the big screen, in his 2007 comedy "Bee Movie".
'The Simpsons' (2001)
Julia Louis-Dreyfus is one of the many, many stars to have lent her voice to "The Simpsons", and she's done it more than once.
Her character — Gloria Jailbird — is the ex-wife of recurring character Snake Jailbird (a.k.a. Professor Chester Turley), who was once engaged to Mr. Burns.
'Watching Ellie' (2002-2003)
Following her history-making run on "Seinfeld", Julia Louis-Dreyfus returned to NBC with her own sitcom, "Watching Ellie".
The series was troubled from the start, and was actually two different shows featuring the same character — nightclub singer Ellie Riggs — and co-stars Steve Carell and Lauren Bowles (her real-life half-sister) but in very different incarnations.
The first version was a single-camera comedy marked by a "24"-style ticking clock, with each episode depicting a 22-minute segment of the character's life. After 10 episodes aired the show disappeared.
It wasn't completely cancelled, returning a year later as a traditional multi-camera sitcom. This version did even worse, and was cancelled , Louis-Dreyfus (whose co-star Lauren Bowles is her real-life half-sister) played cabaret singer Ellie episodes were filmed but only ten aired before the series was put on indefinite hiatus (the remaining first-season episodes have never aired).
Nearly a full year later, the show reappeared as a more traditional sitcom, with multiple cameras and a live studio audience (plus an added laugh track). This version fared even worse than its predecessor and was canceled after six episodes.
'Arrested Development' (2004)
In 2004, Julia Louis-Dreyfus made what would be the first of several appearances on "Arrested Development", guest starring in the first season as blind lawyer Maggie Lizer, who has a romance with Michael Bluth (Jason Bateman).
It's later revealed that Maggie isn't blind, and that pretty much every word out of her mouth is a lie, which puts her nickname — "Maggie Lizer a** off" — in a whole new light.
'The New Adventures of Old Christine' (2006-2010)
While "Watching Ellie" was an undisputed bomb, Julia Louis-Dreyfus' next TV project certainly wasn't.
In "The New Adventures of Old Christine", she plays a recently divorced mother whose ex-husband (future "Agents of S.H.I.E.L.D." star Clark Gregg) has a new, younger wife who's also named Christine, a.k.a. New Christine. Wanda Sykes played Old Christine's best friend.
The CBS series ran for five successful seasons, earning nine Emmy nominations and granting Louis-Dreyfus her second Emmy win.
'Curb Your Enthusiasm' (2009)
"Seinfeld" fans received a special treat in the seventh season of series co-creator Larry David's solo series, "Curb Your Enthusiasm", which focused on reuniting the cast for a "Seinfeld" reunion.
Julia Louis-Dreyfus joined Jerry Seinfeld, Michael Richards and Jason Alexader for the faux reunion that will likely be the closest thing fans will see to an actual one.
'30 Rock' (2010)
Julia Louis-Dreyfus made a surprise appearance during a live episode of "30 Rock", portraying Tina Fey's Liz Lemon in a scene with Alec Baldwin's Jack Donaghy.
In the brief exchange, Louis-Dreyfus makes a quick exit when an identically dressed Fey shows up, and she hands off to her.
The success of "Old Christine" was just a warmup of the success that came with Julia Louis-Dreyfus' next project, HBO comedy "Veep".
Playing perpetually beleaguered Vice President Selina Meyer won Louis-Dreyfus mountains of critical acclaim and a whopping six Emmy wins.
'Enough Said' (2013)
In the midst of "Veep", Julia Louis-Dreyfus co-starred in the romantic comedy "Enough Said".
I the film, she portrays a divorced massage therapist who falls for a burly guy named Albert (the late James Gandolfini), only to subsequently discover he's the ex-husband of one a close friend.
'Inside Amy Schumer' (2015)
Julia Louis-Dreyfus starred alongside Tina Fey and Patricia Arquette in a hilariously edgy sketch for Amy Schumer's Comedy Central series. In the bit, the three actresses are having a picnic to celebrate their "last f**kable day," before Hollywood deems them too old and relegates them to playing moms and grandmas.
As she said in an interview, the sketch actually hit a little closer to home than she thought it would. "I started to feel unbelievably paranoid that I was making fun of myself, and wondering, was this really happening to me? Like, how meta is this moment in my life?" she said.
"I started to have a kind of soul-searching crisis in the middle of the day," she explained. "And I didn't know [the other women] well enough to bring it up, so I was just trying to be a good sport even though I was dying a little bit on the inside."
Democratic National Convention (2020)
A staunch Democrat, Julia Louis-Dreyfus brought some laughs to the 2020 Democratic National Convention, giving a speech on behalf of future President Joe Biden, and naturally she hilariously torched Trump.
“Tonight, I couldn’t be prouder to be a loyal union member, a passionate climate activist, and a patriotic Democrat,” she said in her speech. “Or as Donald Trump will call me in a tweet tomorrow, ‘a washed-up, horse-face, no-talent has-been with low ratings.’ Well, with all due respect, sir, it takes one to know one.”