'Another World' - 1987-1991
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Heche came to prominence on the soap opera "Another World", starring as twins Vicky Hudson and Marley Love, earning her a Daytime Emmy Award and two Soap Opera Digest Awards for her performance.
'Walking and Talking' - 1996
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Heche delivered an acclaimed performance in Nicole Holofcener's 1996 ensemble comedy-drama "Walking and Talking", with co-stars Catherine Keener, Liev Schreiber and Todd Field.
In the film, Heche plays Laura, who's engagement sets off a journey through anxiety and self-exploration for her best friend Amelia.
'Donnie Brasco' - 1997
After a string of roles in film and television through the '90s, Heche began to get wider recognition starring opposite Johnny Depp in the 1997 crime-drama "Donnie Brasco", which also starred Al Pacino, Michael Madsen, and more.
'Volcano' - 1997
In 1997, Heche also starred in the blockbuster disaster movie "Volcano", alongside Tommy Lee Jones, Gaby Hoffman, Don Cheadle, and more.
The film is about a volcano that erupts in downtown Los Angeles, with Heche playing seismologist Dr. Amy Barnes, who works with a city official to try and stop the devastating lava flow.
'John Q' - 2001
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In the thriller "John Q", Anne Heche played an administrator at a hospital where Denzel Washington's character has taken people hostage, demanding his son receive a heart transplant after learning his health insurance won't cover the procedure.
'I Know What You Did Last Summer' - 1997
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Heche had a small but crucial role in the 1997 slasher movie hit "I Know What You Did Last Summer", playing the sister of the man the main characters think they ran over in their car.
'Wag The Dog' - 1997
Heche continued her winning 1997 with her role as presidential aide Winifred Ames in the sharp American political satire "Wag the Dog", co-starring Dustin Hoffman and Robert De Niro.
'Six Days, Seven Nights' - 1998
Heche took the lead opposite Harrison Ford in the 1998 action-adventure "Six Days, Seven Nights", about a New York magazine editor who must team up with a pilot, putting aside their dislike of each other, in order to survive after crash landing on a deserted island.
'Psycho' - 1998
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In 1998, Heche took on one of the most iconic roles in cinema history, playing Marion Crane in Gus Van Sant's remake of "Psycho".
Originally played by Janet Leigh, the character becomes the the victim of serial killer Norman Bates.
'Birth' - 2004
Heche appeared in a significant supporting role in the acclaimed Jonathan Glazer drama "Birth", starring Nicole Kidman.
The film tells the story of a boy who tries to convince a woman that he is her late husband reborn.
'Everwood' - 2004-2005
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Heche appeared in the third season of the hit drama series "Everwood", playing Amanda Hayes, who has an affair with Treat Williams' lead character Andy.
'Hung' - 2009
Heche starred as Jessica, the ex-wife of Thomas Jane's character Ray Drecker in the HBO series "Hung", about a man with a nine-inch penis who becomes a male prostitute.
'Cedar Rapids' - 2011
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In 2011, Heche starred opposite Ed Helms in the comedy "Cedar Rapids", about a man who gets more than he bargained for at an annual insurance convention.
'The Brave' - 2017-2018
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Heche starred in the single-season drama "The Brave", about an elite covert ops team exploring the dangerous missions they go on, as well as the personal toll their work takes.
The actress played Patricia Campbell, the deputy director of the American Defense Intelligence Agency.
'Chicago P.D.' - 2018-2019
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Heche took on a recurring role in season 6 of "Chicago P.D.", playing Deputy Superintendent Katherine Brennan.